Co-treatment with Spirulina platensis aqueous extract (SPAE) led to a dose-dependent reduction in Keap1 expression, with the 800 mg/kg dose showing the most pronounced effect (0.80 0.05), significantly lower than both the DEX and SPAE 400 mg/kg groups (1.20 0.07)
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Phase 2 trial in type 2 diabetes (Lancet 2023) showed similar additive benefit for the combination
While both peptides are effective in promoting healing, they target different aspects of the recovery process
Allows confirmation that an effect is centrally mediated rather than peripheral
